期刊
CELL METABOLISM
卷 16, 期 6, 页码 833-845出版社
CELL PRESS
DOI: 10.1016/j.cmet.2012.11.004
关键词
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资金
- Blasker Science and Technology Grant Award from the San Diego Foundation
- NIH NRSA post-doctoral fellowship [F32-HG004830]
- Mary K. Chapman Foundation
- Howard Hughes Medical Institute
- Gordon and Betty Moore foundation
- Pew Scholars Program in Biomedical Sciences
- NIH [DK091618, HG004659, GM084317, NS075449]
In the mouse liver, circadian transcriptional rhythms are necessary for metabolic homeostasis. Whether dynamic epigenomic modifications are associated with transcript oscillations has not been systematically investigated. We found that several antisense RNA, lincRNA, and microRNA transcripts also showed circadian oscillations in adult mouse livers. Robust transcript oscillations often correlated with rhythmic histone modifications in promoters, gene bodies, or enhancers, although promoter DNA methylation levels were relatively stable. Such integrative analyses identified oscillating expression of an antisense transcript (asPer2) to the gene encoding the circadian oscillator component Per2. Robust transcript oscillations often accompanied rhythms in multiple histone modifications and recruitment of multiple chromatin-associated clock components. Coupling of cycling histone modifications with nearby oscillating transcripts thus established a temporal relationship between enhancers, genes, and transcripts on a genome-wide scale in a mammalian liver. The results offer a framework for understanding the dynamics of metabolism, circadian clock, and chromatin modifications involved in metabolic homeostasis.
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