期刊
CELL METABOLISM
卷 16, 期 4, 页码 420-434出版社
CELL PRESS
DOI: 10.1016/j.cmet.2012.06.017
关键词
-
资金
- NIH [HL49094, HL67330, HL70694, HL89934, CA154481]
- Breast Cancer Research Foundation
- Botwinick-Wolfensohn Foundation
Sphingolipids, ubiquitous membrane lipids in eukaryotes, carry out a myriad of critical cellular functions. The past two decades have seen significant advances in sphingolipid research, and in 2010 a first sphingolipid receptor modulator was employed as a human therapeutic. Furthermore, cellular signaling mechanisms regulated by sphingolipids are being recognized as critical players in metabolic diseases. This review focuses on recent advances in cellular and physiological mechanisms of sphingolipid regulation and how sphingolipid signaling influences metabolic diseases. Progress in this area may contribute to new understanding and therapeutic options in complex diseases such as atherosclerosis, diabetes, metabolic syndromes, and cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据