期刊
CELL METABOLISM
卷 13, 期 1, 页码 11-22出版社
CELL PRESS
DOI: 10.1016/j.cmet.2010.12.008
关键词
-
资金
- National Institutes of Health [R37-AI33443, RO1-AI068977, RO1 AI066109]
Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-kappa B in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.
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