期刊
CELL METABOLISM
卷 13, 期 2, 页码 125-137出版社
CELL PRESS
DOI: 10.1016/j.cmet.2011.01.006
关键词
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资金
- Swiss National Foundation [SNF 31-113565, SNF 31-128656/1]
- NCCR
- European Research Council [ERC-2009-AdG 20090506]
- State of Geneva
- Louis Jeantet Foundation of Medicine
- European Framework Project EUCLOCK
- EMBO
- Human Frontier Science Program
In mammals, most metabolic processes are influenced by biological clocks and feeding rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging. NAD-dependent enzymes (e.g., Sirtuins and poly[ADP-ribose] polymerases), redox- and/or temperature-dependent transcription factors (e.g., CLOCK, NPAS2, and HSF1), nutrient-sensing transcriptional regulatory proteins (e.g., CREB-CBP-CRCT2, FOXO-p300, nuclear receptors, PGC-1, and SP1 family members) and protein kinases (e.g., AMPK), are plausible candidates for conveying a cell's metabolic state to the core clock circuitry. The intertwining between these acute regulators and circadian clock components is so tight that the discrimination between metabolic and circadian oscillations may be somewhat arbitrary.
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