期刊
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
卷 35, 期 6, 页码 577-598出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/B:JOBB.0000008025.65675.37
关键词
T-type; review; alpha1G (Ca(v)3.1); alpha1H (Ca(v)3.2); alpha1I (Ca(v)3.3); epilepsy; cardiac; vascular; pharmacology
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH055747, R29MH055747] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH55747] Funding Source: Medline
Although T-type calcium channel currents were observed almost 30 years ago, the genes that encode the pore-forming subunits have only been recently reported. When expressed in heterologous systems, three distinct alpha1 subunits (alpha1G (Ca(v)3.1), alpha1H (Ca(v)3.2), and alpha1I (Ca(v)3.3)) conduct T-type currents with insert similar but not identical electrophysiological characteristics that. Alpha1G, alpha1H, and alpha1I transcripts are found throughout neural and nonneural tissues, suggesting multiple types of T-type channels (also called low voltage-activated calcium channels (LVAs)) are coexpressed by many tissues. The study of endogenous LVAs has been hampered by a lack of highly selective antagonists that differentiate between LVA subtypes. Furthermore, many pharmacological agents attenuate currents conducted by LVA and high voltage-activated calcium channels (HVAs). At least 15 classes of pharmacological agents affect T-type currents, and the therapeutic use of many of these drugs has implicated LVAs in the etiology of a variety of diseases. Comparison of the responses of recombinant and native LVAs to pharmacological agents and endogenous modulatory molecules will lead to a better understanding of LVAs in normal and diseased cells.
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