期刊
CELL METABOLISM
卷 12, 期 5, 页码 496-508出版社
CELL PRESS
DOI: 10.1016/j.cmet.2010.09.016
关键词
-
资金
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicale
- College de France
- National Institute of Health [DK59820]
- Association Francaise contre lea Myopathies (AFM)
- Fondation pour la Recherche Medicale
- Association pour la recherche a l'IGBMC (ARI)
- ARI
- Boehringer Ingelheim
The two p160 transcriptional coregulator family members SRC-1 and TIF2 have important metabolic functions in white and brown adipose tissues as well as in the liver. To analyze TIF2 cell-autonomous functions in skeletal muscles, we generated TIF2((i)skm-/-) mice in which TIF2 was selectively ablated in skeletal muscle myofibers at adulthood. We found that increased mitochondrial uncoupling in skeletal muscle myocytes protected these mice from decreased muscle oxidative capacities induced by sedentariness, delayed the development of type 2 diabetes, and attenuated high-caloric-diet-induced obesity. Moreover, our results demonstrate that SRC-1 and TIF2 can modulate the expression of the uncoupling protein 3 (UCP3) in an antagonistic manner and that enhanced SRC-1 levels in TIF2-deficient myofibers are critically involved in the metabolic changes of TIF2((1)skm-/-) mice. Thus, modulation of the expression and/or activity of these coregulators represents an attractive way to prevent or treat metabolic disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据