期刊
TRENDS IN CARDIOVASCULAR MEDICINE
卷 13, 期 1, 页码 15-21出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S1050-1738(02)00188-3
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资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL072016] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R56AR040849, R01AR040849] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL072016] Funding Source: Medline
- NIAMS NIH HHS [AR40849] Funding Source: Medline
Modulatory calcineurin-interacting proteins (MCIPs), also known as the Down syndrome critical region 1 (DSCR1) and DSCR1-like proteins, are a recently described family of small, structurally related proteins that are preferentially expressed in heart, skeletal muscle, and brain. MCIP proteins can bind to and inhibit calcineurin, a calcium/calmodulin-regulated serine/threonine protein phosphatase that is activated during cardiac hypertrophy and failure. Transcription of the mammalian MCIP1 gene is induced by calcineurin, suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction. Forced expression of human MCIP1 protein in the hearts of transgenic mice attenuates the hypertrophic response to a broad range of stimuli. This review summarizes work from a number of laboratories on the structure, regulation, and function of MCIP proteins. (C) 2003 Elsevier Science Inc.
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