期刊
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
卷 25, 期 4, 页码 491-501出版社
MARCEL DEKKER INC
DOI: 10.1081/IPH-120026435
关键词
Bojungikki-tang; chronic fatigue syndrome; lipopolysaccharide; cytokines
Bojungikki-tang (BIT) has been widely used to treat patients suffering from chronic fatigue syndrome (CFS). However, its effect has not been yet investigated experimentally. Based upon the clinical presentation of CFS, we hypothesized that cytokines may play a role in the pathogenesis of the disease. We studied the effect of BIT on lipopolysaccharide (LPS)-induced various cytokines production in peripheral blood mononuclear cells (PBMC) of CFS patients. Bojungikki-tang (1 mg/mL) significantly inhibited LPS-induced tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-10, transforming growth factor (TNF)-beta1 production by 63.55% +/- 0.19%, 55.06% +/- 0.27%, 48.23% +/- 0.48%, 54.09% +/- 0.76%, respectively (P < 0.05). Bojungikki-tang showed a slightly lower inhibitory effect of LPS-induced Interferon (IFN)-γ production. These results suggest that BIT may be useful in treating fatigue associated with chronic diseases.
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