期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 15, 期 3, 页码 132-142出版社
KARGER
DOI: 10.1159/000068484
关键词
Alzheimer's disease; mild cognitive impairment; depression; kinematic handwriting analysis; digitizing graphic tablet; automation; Mini Mental State Examination
A variety of studies have demonstrated that motor disorders, parkinsonism and extrapyramidal motor symptoms (EPMS) are common in patients with Alzheimer's disease (AD). Several studies have reported an association of EPMS with severity, progression and poor prognosis of AD. The majority of these studies used clinical assessments for the rating of EPMS. In this study, kinematic handwriting analysis was used to quantify differences in fine hand motor function in patients with probable AD and mild cognitive impairment (MCl, as an assumed initial stage of AD) compared to depressed patients and healthy controls. Both patients with MCl and patients with probable AD exhibited loss of fine motor performance. Movements of AD patients were significantly less regular than those of healthy controls. Copyright (C) 2003 S. Karger AG, Basel.
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