期刊
APOPTOSIS
卷 8, 期 1, 页码 55-60出版社
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1021649019025
关键词
apoptosis; breast cancer; cell proliferation; estrogen
资金
- NATIONAL CANCER INSTITUTE [R01CA065622] Funding Source: NIH RePORTER
- NCI NIH HHS [CA 65622] Funding Source: Medline
Estrogen as a mitogen stimulates cell proliferation and prevents cell death in many cell types. In patients, estrogen is known to stimulate breast and uterus cancer development. Ironically, high doses of estrogen can induce regression of hormone-dependent breast cancer in postmenopausal women. The comprehensive mechanism by which estrogen induces tumor recession in breast cancer is still unknown, but activation of the Fas/FasL pathways plays a key role in this process. Laboratory studies show that the apoptotic action of estrogen is the major factor leading to cell number decreases in several cell types. The effects of estrogen are estrogen-receptor dependent. In this mini review, we will focus on the latest findings regarding estrogen apoptotic effects in several cell models, including breast cancer cells, and summarize the possible mechanisms involved in these estrogen mediated processes. New potential implications for the pharmacological control of breast cancer with estrogen in post-menopausal women are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据