期刊
CELL METABOLISM
卷 7, 期 6, 页码 469-471出版社
CELL PRESS
DOI: 10.1016/j.cmet.2008.05.001
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资金
- NHLBI NIH HHS [R01 HL060306, R01 HL036709] Funding Source: Medline
Niemann-Pick C1-like 1 (NPC1L1) is a target for ezetimibe, a drug that blocks intestinal cholesterol absorption. A new study by Ge et al. (2008) in this issue of Cell Metabolism shows that non-lipoprotein-bound cholesterol induces endocytosis of NPC1L1 and that ezetimibe blocks the internalization of the NPC1L1/cholesterol complex. The in vivo significance of these findings is discussed.
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