期刊
CELL HOST & MICROBE
卷 15, 期 1, 页码 47-57出版社
CELL PRESS
DOI: 10.1016/j.chom.2013.12.007
关键词
-
资金
- National Institutes of Health [DK089121, GM103574, GM083343]
Genomic and metagenomic sequencing efforts, including human microbiome projects, reveal that microbes often encode multiple systems that appear to accomplish the same task. Whether these predictions reflect actual functional redundancies is unclear. We report that the prominent human gut symbiont Bacteroides thetaiotaomicron employs three functional, homologous vitamin B-12 transporters that in at least two cases confer a competitive advantage in the presence of distinct B-12 analogs (corrinoids). In the mammalian gut, microbial fitness can be determined by the presence or absence of a single transporter. The total number of distinct corrinoid transporter families in the human gut microbiome likely exceeds those observed in B. thetaiotaomicron by an order of magnitude. These results demonstrate that human gut microbes use elaborate mechanisms to capture and differentiate corrinoids in vivo and that apparent redundancies observed in these genomes can instead reflect hidden specificities that determine whether a microbe will colonize its host.
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