期刊
CELL HOST & MICROBE
卷 16, 期 6, 页码 748-758出版社
CELL PRESS
DOI: 10.1016/j.chom.2014.10.018
关键词
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资金
- NIH [R01GM092893, R01GM097247]
- NSF [IOS-1252539, MCB-0950459]
- Robert A. Welch Foundation [A-1795]
- Texas AgriLife Genomics Seed Grant
- China Scholarship Council
- Rio de Janeiro State Research Foundation (FAPERJ), Brazil
- NSF REU program
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1358941] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1252539, 1146589] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0950459] Funding Source: National Science Foundation
Perception of microbe-associated molecular patterns (MAMPs) elicits host transcriptional reprogramming as part of the immune response. Although pathogen perception is well studied, the signaling networks orchestrating immune gene expression remain less clear. In a genetic screen for components involved in the early immune gene transcription reprogramming, we identified Arabidopsis RNA polymerase II C-terminal domain (CTD) phosphatase-like 3 (CPL3) as a negative regulator of immune gene expression. MAMP perception induced rapid and transient cyclin-dependent kinase C (CDKC)-mediated phosphorylation of Arabidopsis CTD. The CDKCs, which are in turn phosphorylated and activated by a canonical MAP kinase (MAPK) cascade, represent a point of signaling convergence downstream of multiple immune receptors. CPL3 directly dephos-phorylated CTD to counteract MAPK-mediated CDKC regulation. Thus, modulation of the phosphorylation dynamics of eukaryotic RNA polymerase II transcription machinery by MAPKs, CTD kinases, and phosphatases constitutes an essential mechanism for rapid orchestration of host immune gene expression and defense upon pathogen attacks.
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