期刊
CELL HOST & MICROBE
卷 14, 期 3, 页码 329-339出版社
CELL PRESS
DOI: 10.1016/j.chom.2013.08.006
关键词
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资金
- LHMP [UO1HL098996]
- Colorado Clinical and Translational Sciences Institute [UL1TR000005]
- Howard Hughes Medical Institute
- [K01DK090285]
Understanding gut microbiota alterations associated with HIV infection and factors that drive these alterations may help explain gut-linked diseases prevalent with HIV. 16S rRNA sequencing of feces from HIV-infected individuals revealed that HIV infection is associated with highly characteristic gut community changes, and antiretroviral therapy does not consistently restore the microbiota to an HIV-negative state. Despite the chronic gut inflammation characteristic of HIV infection, the associated microbiota showed limited similarity with other inflammatory states and instead showed increased, rather than decreased, diversity. Meta-analysis revealed that the microbiota of HIV-infected individuals in the U. S. was most similar to a Prevotella-rich community composition typically observed in healthy individuals in agrarian cultures of Malawi and Venezuela and related to that of U. S. individuals with carbohydrate-rich, protein-and fat-poor diets. By evaluating innate and adaptive immune responses to lysates from bacteria that differ with HIV, we explore the functional drivers of these compositional differences.
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