期刊
CELL HOST & MICROBE
卷 12, 期 4, 页码 396-407出版社
CELL PRESS
DOI: 10.1016/j.chom.2012.09.008
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [UM1 AI100663, R01 AI084817] Funding Source: Medline
- NIDDK NIH HHS [R37 DK057665] Funding Source: Medline
Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined two HIV vaccines. Here, we argue for an approach based, in part, on understanding the HIV envelope spike and its interaction with broadly neutralizing antibodies (bnAbs) at the molecular level and using this understanding to design immunogens as possible vaccines. BnAbs can protect against virus challenge in animal models, and many such antibodies have been isolated recently. We further propose that studies focused on how best to provide T cell help to B cells that produce bnAbs are crucial for optimal immunization strategies. The synthesis of rational immunogen design and immunization strategies, together with iterative improvements, offers great promise for advancing toward an HIV vaccine.
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