期刊
CELL HOST & MICROBE
卷 11, 期 1, 页码 1-2出版社
CELL PRESS
DOI: 10.1016/j.chom.2012.01.002
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资金
- NIAID NIH HHS [R01 AI087625, R01AI087625, RC4 AI092801, RC4AI092801] Funding Source: Medline
Plasmodium falciparum PfEMP1 is a malaria virulence protein whose expression is epigenetically regulated. The parasite's ability to express exclusively only one of the sixty var genes that encode PfEMP1 is essential for disease pathogenesis. Two recent papers identify key molecular players in determining whether a var gene is active or silenced (Volz et al., 2012; Zhang et al., 2011).
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