期刊
CELL HOST & MICROBE
卷 6, 期 5, 页码 433-445出版社
CELL PRESS
DOI: 10.1016/j.chom.2009.09.013
关键词
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资金
- Ann Hill for MEFs, Wayne Yokoyama [CPXV-6203]
- McFadden for pT7 E/L EGFP-GPT
- Dutch Cancer Foundation [RUL 2005-3259]
- Natural Sciences and Engineering Research Council
- MAID [HHSN266200400036C]
- [A1077048]
- [RR00163]
- [A0076506]
Cowpox virus encodes an extensive array of putative immunomodulatory proteins, likely contributing to its wide host range, which includes zoonotic infections in humans. Unlike Vaccinia virus, cowpox virus prevents stimulation of CD8(+) T cells, a block that correlated with retention of MHC class I in the endoplasmic reticulum by the cowpox virus protein CPXV203. However, deletion of CPX203 did not restore MHC class I transport or T cell stimulation. Here, we demonstrate the contribution of an additional viral protein, CPXV12, which interferes with MHC class I/peptide complex formation by inhibiting peptide translocation by the transporter associated with antigen processing (TAP). Importantly, human and mouse MHC class I transport and T cell stimulation was restored upon deletion of both CPXV12 and CPXV203, suggesting that these unrelated proteins independently mediate T cell evasion in multiple hosts. CPXV12 is a truncated version of a putative NK cell ligand, indicating that poxviral gene fragments can encode new, unexpected functions.
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