期刊
CELL HOST & MICROBE
卷 5, 期 6, 页码 527-549出版社
CELL PRESS
DOI: 10.1016/j.chom.2009.05.016
关键词
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资金
- National Institutes of Health [A1069345, A145148, A142999, Al151267, CA109618]
- amfAR [107160-44-RGRL]
- Bill and Melinda Gates Grand Challenge Explorations [52068]
- Crohn's and Colitis Foundation of America
- Ellison Medical Foundation
Autophagy adjusts cellular biomass and function in response to diverse stimuli, including infection. Autophagy plays specific roles in shaping immune system development, fueling host innate and adaptive immune responses, and directly controlling intracellular microbes as a cell-autonomous innate defense. As an evolutionary counterpoint, intracellular pathogens have evolved to block autophagic microbicidal defense and subvert host autophagic responses for their survival or growth. The ability of eukaryotic pathogens to deploy their own autophagic machinery may also contribute to microbial pathogenesis. Thus, a complex interplay between autophagy and microbial adaptations against autophagy governs the net outcome of host-microbe encounters.
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