期刊
CELL HOST & MICROBE
卷 5, 期 5, 页码 450-462出版社
CELL PRESS
DOI: 10.1016/j.chom.2009.04.012
关键词
-
资金
- NIH
- [NIDDK R01DK074731]
- [MAID R01Al056067]
Caenorhabditis elegans exhibits avoidance behavior when presented with diverse bacterial pathogens. We hypothesized that exposure to pathogens might not only cause worms to move away but also simultaneously activate pathways that promote resistance to the pathogen. We show that brief exposure to virulent or avirulent strains of the bacterial pathogen enteropathogenic E. coli (EPEC) immunizes C. elegans to survive a subsequent exposure that would otherwise prove lethal, a phenomenon we refer to as conditioning. Conditioning requires dopaminergic neurons; the p38 MAP kinase pathway, which regulates innate immunity; and the insulin/IGFR pathway, which regulates lifespan. Our findings suggest that the molecular pathways that control innate immunity and lifespan may be regulated or conditioned by exposure to pathogens to allow survival in noxious environments.
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