Eating Twice for the Sake of Immunity: A Phagocytic Receptor that Activates Autophagy

The mechanism by which the cell responds to invading pathogens is an area of intense research. Joubert et al. (2009) have found that the phagocytic receptor CD46 is able to activate autophagy through a tripartite interaction between itself, a scaffold protein GOPC, and the autophagy inducer complex of Beclin1-VPS34.