期刊
CELL HOST & MICROBE
卷 3, 期 4, 页码 206-212出版社
CELL PRESS
DOI: 10.1016/j.chom.2008.03.004
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R37 GM045443, R37 GM045443-17] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R37GM045443] Funding Source: NIH RePORTER
Eukaryotic mRNAs are in a dynamic equilibrium between different subcellular locations. Translating mRNAs can be found in polysomes, mRNAs stalled in translation initiation accumulate in stress granules and mRNAs targeted for degradation or translation repression can accumulate in P bodies. Partitioning of mRNAs between polysomes, stress granules, and P bodies affects rates of translation and mRNA degradation. Host proteins within P bodies and stress granules can enhance or limit viral infection, and some viral RNAs and proteins accumulate in P bodies and/or stress granules. Thus, an important interplay among P bodies, stress granules, and viral life cycles is beginning to emerge.
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