期刊
CANCER AND METASTASIS REVIEWS
卷 22, 期 4, 页码 395-403出版社
SPRINGER
DOI: 10.1023/A:1023781114568
关键词
apoptosis; invasion; MAPK; metastasis; migration; proteinases
类别
资金
- NCI NIH HHS [R01 CA 83964] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA083964] Funding Source: NIH RePORTER
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.
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