期刊
ANNUAL REVIEW OF MICROBIOLOGY
卷 57, 期 -, 页码 641-676出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.57.030502.091033
关键词
tuberculosis; latency; granuloma; virulence; macrophage
类别
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL064550] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI036396, R21AI047744, R01AI047744] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL64550] Funding Source: Medline
- NIAID NIH HHS [AI 36396, AI 47744] Funding Source: Medline
Pathogenic mycobacteria, including the causative agents of tuberculosis and leprosy, are responsible for considerable morbidity and mortality worldwide. A hallmark of these pathogens is their tendency to establish chronic infections that produce similar pathologies in a variety of hosts. During infection, mycobacteria reside in macrophages and induce the formation of granulomas, organized immune complexes of differentiated macrophages, lymphocytes, and other cells. This review summarizes our understanding of Mycobacterium-host cell interactions, the bacterial-granuloma interface, and mechanisms of bacterial virulence and persistence. In addition, we highlight current controversies and unanswered questions in these areas.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据