期刊
CELL DEATH AND DIFFERENTIATION
卷 21, 期 1, 页码 26-38出版社
SPRINGERNATURE
DOI: 10.1038/cdd.2013.48
关键词
immunogenic cell death; DAMPs; danger signals; cancer; immunogenicity; tumour immunology; anti-tumour immunity
资金
- Fund for Scientific Research Flanders (FWO-Vlaanderen) [G. 0661.09, G. 0728.10, G. 0584.12N]
- KU Leuven [GOA/11/009, PDMK/12/146]
- Interuniversity Attraction Poles Programme [IAP7/32]
- European Regional Development Fund through Innovative Economy grant [POIG.01.01.02-00-008/08]
- Foundation for Polish Science
- EU European Regional Development Fund
Accumulating data indicates that following anti-cancer treatments, cancer cell death can be perceived as immunogenic or tolerogenic by the immune system. The former is made possible due to the ability of certain anti-cancer modalities to induce immunogenic cell death (ICD) that is associated with the emission of damage-associated molecular patterns (DAMPs), which assist in unlocking a sequence of events leading to the development of anti-tumour immunity. In response to ICD inducers, activation of endoplasmic reticulum (ER) stress has been identified to be indispensable to confer the immunogenic character of cancer cell death, due to its ability to coordinate the danger signalling pathways responsible for the trafficking of vital DAMPs and subsequent anti-cancer immune responses. However, in recent times, certain processes apart from ER stress have emerged (e.g., autophagy and possibly viral response-like signature), which have the ability to influence danger signalling. In this review, we discuss the molecular nature, emerging plasticity in the danger signalling mechanisms and immunological impact of known DAMPs in the context of immunogenic cancer cell death. We also discuss key effector mechanisms modulating the interface between dying cancer cells and the immune cells, which we believe are crucial for the therapeutic relevance of ICD in the context of human cancers, and also discuss the influence of experimental conditions and animal models on these.
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