期刊
CELL DEATH AND DIFFERENTIATION
卷 20, 期 8, 页码 976-986出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2013.50
关键词
glycans; lectins; galectins; apoptosis; autophagy
资金
- National Multiple Sclerosis Society (USA)
- Prostate Action (UK)
- National Agency for Promotion of Science and Technology (Argentina)
- University of Buenos Aires (Argentina)
- National Council of Scientific and Technical Investigations (CONICET, Argentina)
- Fundacion Sales (Argentina)
- Ministry of Industry, Trade and Labor (Israel)
- Ministry of Science and Technology (Israel)
Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings.
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