期刊
CELL DEATH AND DIFFERENTIATION
卷 20, 期 1, 页码 43-48出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2012.73
关键词
selective autophagy; autophagosome; ATG genes; yeast; Atg11
资金
- Hamaguchi Foundation for the Advancement of Biochemistry
- NOVARTIS Foundation (Japan) for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [24657083] Funding Source: KAKEN
Autophagy is a bulk degradation system, widely conserved in eukaryotes. Upon starvation, autophagosomes enclose a portion of the cytoplasm and ultimately fuse with the vacuole. The contents of autophagosomes are degraded in the vacuole, and recycled to maintain the intracellular amino-acid pool required for protein synthesis and survival under starvation conditions. Previously, autophagy was thought to be an essentially nonselective pathway, but recent evidence suggests that autophagosomes carry selected cargoes. These studies have identified two categories of selective autophagy - one highly selective and dependent on autophagy-related 11 (Atg11); another, less selective, that is, independent of Atg11. The former, selective category comprises the Cvt pathway, mitophagy, pexophagy and piecemeal microautophagy of the nucleus; acetaldehyde dehydrogenase 6 degradation and ribophagy belong to the latter, less selective category. In this review, I focus on the mechanisms and the physiological roles of these selective types of autophagy. Cell Death and Differentiation (2013) 20, 43-48; doi:10.1038/cdd.2012.73; published online 15 June 2012
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