期刊
CELL DEATH AND DIFFERENTIATION
卷 19, 期 6, 页码 1080-1089出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2011.192
关键词
cell murder; assisted cell suicide; ephrin; oocyte; engulfment
资金
- NIH National Center for Research Resources (NCRR)
- National Science Foundation (NSF)
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0949489] Funding Source: National Science Foundation
Programmed cell death eliminates unwanted cells during normal development and physiological homeostasis. While cell interactions can influence apoptosis as they do other types of cell fate, outside of the adaptive immune system little is known about the intercellular cues that actively promote cell death in healthy cells. We used the Caenorhabditis elegans germline as a model to investigate the extrinsic regulators of physiological apoptosis. Using genetic and cell biological methods, we show that somatic gonad sheath cells, which also act as phagocytes of dying germ cells, promote death in the C. elegans germline through VAB-1/Eph receptor signaling. We report that the germline apoptosis function of VAB-1 impacts specific cell death pathways, and may act in parallel to extracellular signal-regulated kinase MAPK signaling. This work defines a non-autonomous, pro-apoptotic signaling for efficient physiological cell death, and highlights the dynamic nature of intercellular communication between dying cells and the phagocytes that remove them. Cell Death and Differentiation (2012) 19, 1080-1089; doi:10.1038/cdd.2011.192; published online 13 January 2012
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