期刊
ANNUAL REVIEW OF MICROBIOLOGY
卷 57, 期 -, 页码 441-466出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.57.030502.090913
关键词
RNA polymerase; Escherichia coli; Bacillus subtilis; Streptomyces coelicolor; cyanobacteria
类别
资金
- NIGMS NIH HHS [GM36278-18, GM57755] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM036278, R37GM036278, R01GM057755] Funding Source: NIH RePORTER
Promoter recognition in eubacteria is carried out by the initiation factor sigma, which binds RNA polymerase and initiates transcription. Cells have one housekeeping factor and a variable number of alternative sigma factors that possess different promoter-recognition properties. The cell can choose from its repertoire of sigmas to alter its transcriptional program in response to stress. Recent structural information illuminates the process of initiation and also shows that the two key sigma domains are structurally conserved, even among diverse family members. We use the sigma repertoire of Escherichia coli, Bacillus subtilis, Streptomyces coelicolor, and cyanobacteria to illustrate the different strategies utilized to organize transcriptional space using multiple sigma factors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据