期刊
CELL DEATH AND DIFFERENTIATION
卷 19, 期 1, 页码 107-120出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2011.96
关键词
autophagy; mitochondrial membrane permeabilization; necroptosis; parthanatos; TNFR1; TP53
资金
- APO-SYS
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0906425] Funding Source: National Science Foundation
- Medical Research Council [MC_U132670600] Funding Source: researchfish
- MRC [MC_U132670600] Funding Source: UKRI
In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations for the definition of distinct cell death morphologies and for the appropriate use of cell death-related terminology, including 'apoptosis', 'necrosis' and 'mitotic catastrophe'. In view of the substantial progress in the biochemical and genetic exploration of cell death, time has come to switch from morphological to molecular definitions of cell death modalities. Here we propose a functional classification of cell death subroutines that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic apoptosis, regulated necrosis, autophagic cell death and mitotic catastrophe. Moreover, we discuss the utility of expressions indicating additional cell death modalities. On the basis of the new, revised NCCD classification, cell death subroutines are defined by a series of precise, measurable biochemical features. Cell Death and Differentiation (2012) 19, 107-120; doi:10.1038/cdd.2011.96; published online 15 July 2011
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