期刊
CELL DEATH AND DIFFERENTIATION
卷 19, 期 1, 页码 36-41出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2011.155
关键词
CD95; caspase-8; apoptosis; C-FLIP; DISC
资金
- Helmholtz Alliance on Systems Biology (NW1SBCancer/UniHD)
- Helmholtz-Russia Joint Research Groups [2008-2]
CD95 (APO-1/Fas) is a member of the death receptor (DR) family. Stimulation of CD95 leads to induction of apoptotic and non-apoptotic signaling pathways. The formation of the CD95 death-inducing signaling complex (DISC) is the initial step of CD95 signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. The activation of procaspase-8 is blocked by cellular FLICE-inhibitory proteins (c-FLIP). This review is focused on the role in the CD95-mediated signaling of the death effector domain-containing proteins procaspase-8 and c-FLIP. We discuss how dynamic cross-talk between procaspase-8 and c-FLIP at the DISC regulates life/death decisions at CD95. Cell Death and Differentiation (2012) 19, 36-41; doi:10.1038/cdd.2011.155; published online 11 November 2011
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