4.7 Article

Mouse granzyme K has pro-inflammatory potential

期刊

CELL DEATH AND DIFFERENTIATION
卷 18, 期 7, 页码 1112-1119

出版社

NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2011.5

关键词

T-killer cell; virus control; orphan granzymes; inflammation

资金

  1. Excellence Initiative of the German Federal and State Governments
  2. Deutsche Forschungsgemeinschaft [BO-1933, GRK1104]
  3. Ministerio de Ciencia e Innovacion (Spain) [SAF2008-02139]
  4. Gobierno de Aragon [PI076/08]
  5. [5RO1AI04494-03]

向作者/读者索取更多资源

Granzymes (gzms) are key components of T-killer (Tc) cells believed to mediate pro-apoptotic activities. Recent evidence suggests that gzms also possess non-cytotoxic activities that contribute to host defense. In this study, we show that Tc cells from lymphocytic choriomeningitis virus (LCMV)-infected wild-type (wt) and gzm A/B-deficient mice express similar levels of gzmK protein, with both mouse strains efficiently controlling infection. GzmK, in recombinant form or secreted by ex vivo-derived LCMV-immune gzmAxB(-/-) Tc cells, lacks pro-apoptotic activity. Instead, gzmK induces primary mouse macrophages to process and secrete interleukin-1 beta, independent of the ATP receptor P2X(7). Together with the finding that IL-1Ra (Anakinra) treatment inhibits virus elimination but not generation of cytotoxic Tc cells in wt mice, the data suggest that Tc cells control LCMV through non-cytotoxic processes that involve gzmK. Cell Death and Differentiation (2011) 18, 1112-1119; doi:10.1038/cdd.2011.5; published online 11 February 2011

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