期刊
CELL DEATH AND DIFFERENTIATION
卷 17, 期 12, 页码 1816-1829出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2010.131
关键词
p73; p73 isoforms; neural stem cells; embryonic neurogenesis; adult neurogenesis
资金
- National Cancer Institute [CA93853]
- Deutsche Krebshilfe [108173]
- NINDS [NS42168]
The p53 family member p73 is essential for brain development, but its precise role and scope remain unclear. Global p73 deficiency determines an overt and highly penetrant brain phenotype marked by cortical hypoplasia with ensuing hydrocephalus and hippocampal dysgenesis. The Delta Np73 isoform is known to function as a prosurvival factor of mature postmitotic neurons. In this study, we define a novel essential role of p73 in the regulation of the neural stem cell compartment. In both embryonic and adult neurogenesis, p73 has a critical role in maintaining an adequate neurogenic pool by promoting self-renewal and proliferation and inhibiting premature senescence of neural stem and early progenitor cells. Thus, products of the p73 gene locus are essential maintenance factors in the central nervous system, whose broad action stretches across the entire differentiation arch from stem cells to mature postmitotic neurons. Cell Death and Differentiation (2010) 17, 1816-1829; doi:10.1038/cdd.2010.131
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