期刊
CELL DEATH AND DIFFERENTIATION
卷 17, 期 2, 页码 215-220出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2009.69
关键词
microRNA; BCL2; CLL; apoptosis; miR15/16 cluster
资金
- Ma'of fellowship
- NIH [R01DK079217]
- University of Texas
- Ladjevardian Regents Research Scholar Fund
MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and suppresses tumorigenicity both in vitro and in vivo. miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma. This review summarizes the discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL. Cell Death and Differentiation (2010) 17, 215-220; doi:10.1038/cdd.2009.69; published online 5 June 2009
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据