相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Should individual PI3 kinase isoforms be targeted in cancer?
Shidong Jia et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
PI 3-kinase and cancer: changing accents
Peter K. Vogt et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2009)
Specific function of phosphoinositide 3-kinase beta in the control of DNA replication
Miriam Marques et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages
Evangelia A. Papakonstanti et al.
JOURNAL OF CELL SCIENCE (2008)
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
Julie Guillermet-Guibert et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Oncogenic signaling of class IPI3K isoforms
A. Denley et al.
ONCOGENE (2008)
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling
Emilio Hirsch et al.
JOURNAL OF ENDOCRINOLOGY (2007)
Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling
Claire Chaussade et al.
BIOCHEMICAL JOURNAL (2007)
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
Barbara Geering et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
John Brognard et al.
MOLECULAR CELL (2007)
IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis
Naira Baregamian et al.
JOURNAL OF SURGICAL RESEARCH (2006)
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors
Masahiko Hayakawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Regulation of apoptosis by insulin-like growth factor (IGF)-I
Ron Kooijman
CYTOKINE & GROWTH FACTOR REVIEWS (2006)
A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling
Zachary A. Knight et al.
CELL (2006)
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
LC Foukas et al.
NATURE (2006)
Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase
S Kang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A pharmacological map of the PI3-K family defines a role for p110 alpha in insulin signaling
Zachary A. Knight et al.
CELL (2006)
PHLPP: A phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth
TY Gao et al.
MOLECULAR CELL (2005)
Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice
SM Brachmann et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors
SF Barnett et al.
BIOCHEMICAL JOURNAL (2005)
High frequency of mutations of the PIK3CA gene in human cancers
Y Samuels et al.
SCIENCE (2004)
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
K Bouzakri et al.
DIABETES (2003)
Early embryonic lethality in mice deficient in the p110 beta catalytic subunit of PI 3-kinase
L Bi et al.
MAMMALIAN GENOME (2002)
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
A Brunet et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
AH Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways
F Hong et al.
LIFE SCIENCES (2001)
Coordinate control of muscle cell survival by distinct insulin-like growth factor activated signaling pathways
MA Lawlor et al.
JOURNAL OF CELL BIOLOGY (2000)
分享论文
