期刊
CELL DEATH AND DIFFERENTIATION
卷 17, 期 2, 页码 221-228出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2009.71
关键词
microRNA; glioblastoma; stem cell; development; brain
资金
- National Institutes of Health
- Esther L Dardinger Endowment for Neuro-oncology and Neurosciences
- Thomas Jeffrey Hayden Foundation
Recent data draw close parallels between cancer, including glial brain tumors, and the biology of stem and progenitor cells. At the same time, it has become clear that one of the major roles that microRNAs play is in the regulation of stem cell biology, differentiation, and cell 'identity'. For example, microRNAs have been increasingly implicated in the regulation of neural differentiation. Interestingly, initial studies in the incurable brain tumor glioblastoma multiforme strongly suggest that microRNAs involved in neural development play a role in this disease. This encourages the idea that certain miRs allow continued tumor growth through the suppression of differentiation and the maintenance of the stem cell-like properties of tumor cells. These concepts will be explored in this article. Cell Death and Differentiation (2010) 17, 221-228; doi:10.1038/cdd.2009.71; published online 12 June 2009
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