期刊
CELL DEATH AND DIFFERENTIATION
卷 17, 期 2, 页码 200-208出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2009.105
关键词
death receptors; apoptosis; microRNA; tumorigenesis; antiapoptotic miRs; proapoptotic miRs
资金
- Associazione Italiana Ricerca sul Cancro, AIRC (GC)
- MIUR-FIRB [RBIN04J4J7]
- EU [503569]
Death receptors, belonging to the TNF receptor superfamily, induce apoptosis through two different pathways, one involving the effector caspases directly (type I cells or mitochondria-independent death), the other one amplifying the death signal through the mitochondrial pathway (type II cells or mitochondria-dependent death). MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate the stability or translational efficiency of targeted messenger RNAs. MiRNAs are involved in many cellular processes that are altered in cancer, such as differentiation, proliferation and apoptosis. In this review we will discuss recent findings implicating miRNAs as regulators of death receptors and pro- and antiapoptotic genes involved in programmed cell death pathways. Cell Death and Differentiation (2010) 17, 200-208; doi:10.1038/cdd.2009.105; published online 31 July 2009
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据