期刊
BRAIN RESEARCH REVIEWS
卷 41, 期 1, 页码 57-78出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-0173(02)00220-5
关键词
schizophrenia; gamma synchrony; 40 Hz; binding; neural connection
Synchronous high frequency (Gamma band) activity has been proposed as a candidate mechanism for the integration or 'binding' of distributed brain activities. Since the first descriptions of schizophrenia, attempts to characterize this disorder have focused on disturbances in such integrative processing. Here, we review both micro- and macroscopic neuroscience research into Gamma synchrony, and its application to understanding schizophrenia. The review encompasses evidence from both animal and human studies for the functional significance of Gamma activity, the association between Gamma dysfunction and information processing disturbances, and the relevance of specific Gamma dysfunctions to the integration and extension of previous disconnection models of schizophrenia. Attention is given to the relationship between Gamma activity and the heterogeneous symptoms of schizophrenia. Existing studies show that measures of Gamma activity have the potential to explain far more of the variance in schizophrenia performance than previous neurophysiological measures. It is concluded that measures of Gamma synchrony offer a valuable window into the core integrative disturbance in schizophrenia cognition. (C) 2002 Elsevier Science B.V. All rights reserved.
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