期刊
CELL DEATH AND DIFFERENTIATION
卷 15, 期 7, 页码 1139-1146出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2008.65
关键词
mitochondria; drosophila; C. elegans; apoptosis; MOMP
资金
- NCI NIH HHS [P01 CA069381-130010, P01 CA069381] Funding Source: Medline
- NIAID NIH HHS [R01 AI047891, R01 AI044828-11, R01 AI040646, R01 AI044828, R01 AI047891-10, R01 AI040646-11] Funding Source: Medline
- NIGMS NIH HHS [R37 GM052735-18, R37 GM052735] Funding Source: Medline
The mitochondrial pathway of cell death, in which apoptosis proceeds following mitochondrial outer membrane permeabilization, release of cytochrome c, and APAF-1 apoptosome-mediated caspase activation, represents the major pathway of physiological apoptosis in vertebrates. However, the well-characterized apoptotic pathways of the invertebrates C. elegans and D. melanogaster indicate that this apoptotic pathway is not universally conserved among animals. This review will compare the role of the mitochondria in the apoptotic programs of mammals, nematodes, and flies, and will survey our knowledge of the apoptotic pathways of other, less familiar model organisms in an effort to explore the evolutionary origins of the mitochondrial pathway of apoptosis.
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