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Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
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von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms
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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
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Hypoxia inducible factor 1α regulates T cell receptor signal transduction
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Hypoxia requires Notch signaling to maintain the undifferentiated cell state
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Genetic evidence for a tumor suppressor role of HIF-2α
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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
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Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice
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Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene
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BRITISH JOURNAL OF CANCER (2004)
Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice
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CARCINOGENESIS (2004)
Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent
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Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
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In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations
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Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes
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Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
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HIF-1α induces cell cycle arrest by functionally counteracting Myc
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Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development
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Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
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The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1α transcriptional activity
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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
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Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 uhiquitin ligase complex
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HIF-1α is essential for myeloid cell-mediated inflammation
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von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
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Inhibition of HIF2 alpha is sufficient to suppress pVHL-defective tumor growth
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Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
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Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
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The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1
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Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys
C Rosenberger et al.
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Structural basis for the recognition of hydroxyproline in αIF-1α by pVHL
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HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron
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The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma
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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
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Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein
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Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
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The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C
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A conserved family of prolyl-4-hydroxylases that modify HIF
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FIH-1:: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
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C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
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HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
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Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease
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VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling
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