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K. Venuprasad et al.
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The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
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Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms
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Itch inhibition regulates chemosensitivity in vitro
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The Need4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch
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TGFβ signalling in control of T-cell-mediated self-reactivity
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Notch signalling during peripheral T-cell activation and differentiation
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Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production
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Itch genetically interacts with Notch1 in a mouse autoimmune disease model
Lydia E. Matesic et al.
HUMAN MOLECULAR GENETICS (2006)
The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X
Rania Mouchantaf et al.
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The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels
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Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation
Paula M. Oliver et al.
IMMUNITY (2006)
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch- dependent ubiquitination
Lucia Di Marcotullio et al.
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Canonical Notch signaling functions as a commitment switch in the epidermal lineage
Cedric Blanpain et al.
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Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains
Patricia Chastagner et al.
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The E3 ubiquitin ligase Itch controls the protein stability of p63
Mario Rossi et al.
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The thymus and T-cell commitment: the right niche for Notch?
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Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice
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Convergence of itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation
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The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIPL turnover
LF Chang et al.
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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change
E Gallagher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation
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Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins
Linda Shearwin-Whyatt et al.
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TAp63α induces apoptosis by activating signaling via death receptors and mitochondria
O Gressner et al.
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Tumor predisposition in mice mutant for p63 and p73:: Evidence for broader tumor suppressor functions for the p53 family
ER Flores et al.
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The cornified envelope: A model of cell death in the skin
E Candi et al.
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The ubiquitin-protein ligase Itch regulates p73 stability
M Rossi et al.
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Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins
EH Hettema et al.
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The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system
A Angers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
V Heissmeyer et al.
NATURE IMMUNOLOGY (2004)
The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells
H Sade et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Itch E3 ligase-mediated regulation of TGF-β signaling by modulating Smad2 phosphorylation
YL Bai et al.
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Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase itch
M Gao et al.
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Mammalian numb proteins promote notch1 receptor ubiquitination and degradation of the notch1 intracellular domain
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mechanisms of TGF-β signaling from cell membrane to the nucleus
YG Shi et al.
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Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel
PC Henry et al.
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p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
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The survival of antigen-stimulated T cells requires NFκB-mediated inhibition of p73 expression
YSY Wan et al.
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The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4
A Marchese et al.
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Conformational flexibility underlies ubiquitin ligation mediated by the WWP1HECT domain E3 ligase
MA Verdecia et al.
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Functional regulation of p73 and p63: development and cancer
G Melino et al.
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Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB
B Hartenstein et al.
EMBO JOURNAL (2002)
Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH
JR Courbard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
ER Flores et al.
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N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel golgi-associated protein
KF Harvey et al.
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Dysregulation of T lymphocyte function in itchy mice: a role for itch in T(H)2 differentiation
DY Fang et al.
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Recognition and ubiquitination of notch by Itch, a hect-type E3 ubiquitin ligase
L Qiu et al.
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Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4
CN Jolliffe et al.
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Role for the p53 homologue p73 in E2F-1-induced apoptosis
M Irwin et al.
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A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
NA Lissy et al.
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