期刊
CELL DEATH AND DIFFERENTIATION
卷 15, 期 6, 页码 959-976出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2008.33
关键词
apoptosis; DNA repair; oxidative stress; survival pathways; transcription factor; tumorigenesis
Depending on multiple factors DNA damage leads either to cell cycle arrest or apoptosis. One of the main players deciding the fate of a cell is the tumor suppressor p53 that modulates these responses in a transcription-dependent and -independent manner. Over the past few years, however, strong evidence accumulated that p53 engages also powerful pro-survival pathways by transcriptionally activating a multitude of genes whose products efficiently counteract apoptosis. Our review summarizes the current knowledge concerning approximately forty p53-regulated proteins that exert their anti-apoptotic potential by interfering with diverse cellular processes. These activities are surely essential for normal development and maintenance of a healthy organism, but may easily turn into the dark side of the tumor suppressor p53 contributing to tumorigenesis.
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