期刊
CELL DEATH AND DIFFERENTIATION
卷 15, 期 4, 页码 678-685出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cdd.2008.21
关键词
hypoxia; cancer; HIF; metastasis
资金
- NCI NIH HHS [T32 CA009151, P01 CA067166, P01 CA067166-12] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P01CA067166, T32CA009151] Funding Source: NIH RePORTER
Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF-alpha) and a constitutive beta subunit (HIF-beta) that facilitate both oxygen delivery and adaptation to oxygen deprivation by regulating the expression of genes that control glucose uptake, metabolism, angiogenesis, erythropoiesis, cell proliferation, and apoptosis. In most experimental models, the HIF pathway is a positive regulator of tumor growth as its inhibition often results in tumor suppression. In clinical samples, HIF is found elevated and correlates with poor patient prognosis in a variety of cancers. In summary, HIF regulates multiple aspects of tumorigenesis, including angiogenesis, proliferation, metabolism, metastasis, differentiation, and response to radiation therapy, making it a critical regulator of the malignant phenotype.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据