期刊
ANNUAL REVIEW OF MICROBIOLOGY
卷 57, 期 -, 页码 609-639出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.57.030502.090824
关键词
KSHV; HHV-8; antiviral immunity; tumor virus; viral oncogenes
类别
资金
- NCI NIH HHS [P01 CA087661, CA67391, CA83485, CA87661, R01 CA121930, R01 CA083485, R01 CA067391] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA121930, R01CA067391, R01CA083485, P01CA087661] Funding Source: NIH RePORTER
Kaposi's sarcoma-associated herpesvirus (KSHV) [or human herpesvirus 8 (HHV-8)] is the most frequent cause of malignancy among AIDS patients. KSHV and related herpesviruses have extensively pirated cellular cDNAs from the host genome, providing a unique opportunity to examine the range of viral mechanisms for controlling cell proliferation. Many of the viral regulatory homologs encode proteins that directly inhibit host adaptive and innate immunity. Other viral proteins target retinoblastoma protein and p53 control of tumor suppressor pathways, which also play key effector roles in intracellular immune responses. The immune evasion strategies employed by KSHV, by targeting tumor suppressor pathways activated during immune system signaling, may lead to inadvertent cell proliferation and tumorigenesis in susceptible hosts.
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