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Prerna Malaney et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer
S-J Kim et al.
ONCOGENE (2016)
Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy
Weiyi Peng et al.
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Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation
Jiawei Guan et al.
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PD-1/PD-L1 blockades in non-small-cell lung cancer therapy
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ONCOTARGETS AND THERAPY (2016)
Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
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The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair
Elizabeth A. Vuono et al.
SCIENTIFIC REPORTS (2016)
Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis
Miriam Stumpf et al.
PLOS ONE (2016)
ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells
Jing-Hong Chen et al.
AUTOPHAGY (2015)
Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure
Lili Gong et al.
CELL CYCLE (2015)
PTEN regulates RPA1 and protects DNA replication forks
Guangxi Wang et al.
CELL RESEARCH (2015)
Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity
Jason Howitt et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2015)
PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
Min-Sik Lee et al.
NATURE COMMUNICATIONS (2015)
PTEN regulates DNA replication progression and stalled fork recovery
Jinxue He et al.
NATURE COMMUNICATIONS (2015)
PTEN stabilizes TOP2A and regulates the DNA decatenation
Xi Kang et al.
SCIENTIFIC REPORTS (2015)
Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN
Hoai-Nghia Nguyen et al.
SCIENTIFIC REPORTS (2015)
PTEN Controls the DNA Replication Process through MCM2 in Response to Replicative Stress
Jiawen Feng et al.
CELL REPORTS (2015)
COSMIC: exploring the world's knowledge of somatic mutations in human cancer
Simon A. Forbes et al.
NUCLEIC ACIDS RESEARCH (2015)
A new class of cancer-associated PTEN mutations defined by membrane translocation defects
H-N Nguyen et al.
ONCOGENE (2015)
Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer
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BIOCHEMICAL PHARMACOLOGY (2014)
Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function
Antonella Papa et al.
CELL (2014)
Is leptin a predictive factor in patients with lung cancer?
Cui-Hong Song et al.
CLINICAL BIOCHEMISTRY (2014)
Therapeutic Targeting of Cancers with Loss of PTEN Function
Lloye M. Dillon et al.
CURRENT DRUG TARGETS (2014)
Plk1 Protein Phosphorylates Phosphatase and Tensin Homolog ( PTEN) and Regulates Its Mitotic Activity during the Cell Cycle
Byeong Hyeok Choi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Phosphorylation of PTEN at STT motif is associated with DNA damage response
Sandip Misra et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2014)
Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium
H. N. Nguyen et al.
ONCOGENE (2014)
Mammalian Lysine Histone Demethylase KDM2A Regulates E2F1-Mediated Gene Transcription in Breast Cancer Cells
Wasia Rizwani et al.
PLOS ONE (2014)
Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities
Hoai-Nghia Nguyen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers
Shingo Nakahata et al.
NATURE COMMUNICATIONS (2014)
PTEN Interacts with Histone H1 and Controls Chromatin Condensation
Zhu Hong Chen et al.
CELL REPORTS (2014)
Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism
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PLOS GENETICS (2014)
Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation
Byeong Hyeok Choi et al.
CELL CYCLE (2013)
Loss of Phosphatase and Tensin Homolog (PTEN) Induces Leptin-mediated Leptin Gene Expression FEED-FORWARD LOOP OPERATING IN THE LUNG
Ravi Ramesh Pathak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress
C. Bassi et al.
SCIENCE (2013)
Reduced expression of PTEN and increased PTEN phosphorylation at residue Ser380 in gastric cancer tissues: A novel mechanism of PTEN inactivation
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CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2013)
Selective Inactivation of PTEN in Smooth Muscle Cells Synergizes With Hypoxia to Induce Severe Pulmonary Hypertension
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JOURNAL OF THE AMERICAN HEART ASSOCIATION (2013)
PTEN interacts with metal-responsive transcription factor 1 and stimulates its transcriptional activity
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BIOCHEMICAL JOURNAL (2012)
Loss of Phosphatase and Tensin Homolog Protein Expression Is an Independent Poor Prognostic Marker in Lung Adenocarcinoma
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JOURNAL OF THORACIC ONCOLOGY (2012)
The functions and regulation of the PTEN tumour suppressor
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent
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CANCER DISCOVERY (2012)
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PHARMACEUTICALS (2012)
Phosphatase and Tensin Homolog on Chromosome 10 Is Phosphorylated in Primary Effusion Lymphoma and Kaposi's Sarcoma
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AMERICAN JOURNAL OF PATHOLOGY (2011)
Phosphorylation/inactivation of PTEN by Akt-independent PI3K signaling in retinal pigment epithelium
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
CREB Is a Novel Nuclear Target of PTEN Phosphatase
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CANCER RESEARCH (2011)
PTEN Positively Regulates UVB-Induced DNA Damage Repair
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CANCER RESEARCH (2011)
Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo
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CELLULAR AND MOLECULAR LIFE SCIENCES (2011)
PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts
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JOURNAL OF NEURO-ONCOLOGY (2011)
Isoform-Specific Phosphoinositide 3-Kinase Inhibitors Exert Distinct Effects in Solid Tumors
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CANCER RESEARCH (2010)
Evaluation of PTEN and Mcl-1 expressions in NSCLC expressing wild-type or mutated EGFR
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MEDICAL ONCOLOGY (2010)
PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR
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CANCER RESEARCH (2009)
High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells
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CELL STEM CELL (2009)
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
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Nuclear PTEN levels and G2 progression in melanoma cells
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MELANOMA RESEARCH (2009)
Elevated Serum Leptin Levels: A Risk Factor for Non-Small-Cell Lung Cancer?
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ONCOLOGY (2009)
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Conditional deletion of Pten causes bronchiolar hyperplasia
Vrushank Dave et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)
PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression
Chun-Ju Chang et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
Shigehisa Yanagi et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain
Leticia Odriozola et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism
Fang Hua et al.
JOURNAL OF IMMUNOLOGY (2007)
A high-quality catalog of the Drosophila melanogaster proteome
Erich Brunner et al.
NATURE BIOTECHNOLOGY (2007)
Essential role for nuclear PTEN in maintaining chromosomal integrity
Wen Hong Shen et al.
CELL (2007)
Ubiquitination regulates PTEN nuclear import and tumor suppression
Lloyd C. Trotman et al.
CELL (2007)
The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation
Ji-Hyun Chung et al.
HUMAN MOLECULAR GENETICS (2006)
Nuclear localization of PTEN by a ran-dependent mechanism enhances apoptosis:: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs
Anabel Gil et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells
Ke Ning et al.
EMBO JOURNAL (2006)
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
JM Tang et al.
LUNG CANCER (2006)
PTEN expression in non-small-cell lung cancer:: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
CJ Marsit et al.
HUMAN PATHOLOGY (2005)
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein
JH Chung et al.
CANCER RESEARCH (2005)
Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells
[Anonymous]
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
F Vazquez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
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