期刊
CELL CYCLE
卷 13, 期 16, 页码 2501-2508出版社
LANDES BIOSCIENCE
DOI: 10.4161/15384101.2014.949124
关键词
cell cycle; mitotic bookmarking; nuclear bodies; nucleolus; Nucleolar Organizer Region (NOR); neo-NOR; neonucleoli; pseudo-NOR; synthetic biology; UBF; 1 degrees; primary; 2 degrees; secondary; CBs; Cajal bodies; CDK; cyclin-dependent kinase; DFC; dense fibrillar component; DJ; distal junction; FCs; fibrillar centers; GC; granular component; HLBs; histone locus bodies; IGS; intergenic spacers; HMG; high mobility group; NBs; nuclear bodies; NORs; nucleolar organizer regions; PJ; proximal junction; PML; promyelocytic leukemia; PNBs; pre-nucleolar bodies; pol; RNA polymerase; pre-rRNA; precursor rRNA; rDNA; ribosomal genes; rRNA; ribosomal RNA; RNP; ribonucleoprotein; TFs; transcription factors; t-UTPs; transcription U 3 proteins; UBF; Upstream binding factor; XEn; Xenopus enhancer
类别
资金
- Science Foundation Ireland (PI) [07/IN.1/B924]
- IRCSET
- Science Foundation Ireland (SFI) [07/IN.1/B924] Funding Source: Science Foundation Ireland (SFI)
The cell nucleus is functionally compartmentalized into numerous membraneless and dynamic, yet defined, bodies. The cell cycle inheritance of these nuclear bodies (NBs) is poorly understood at the molecular level. In higher eukaryotes, their propagation is challenged by cell division through an open mitosis, where the nuclear envelope disassembles along with most NBs. A deeper understanding of the mechanisms involved can be achieved using the engineering principles of synthetic biology to construct artificial NBs. Successful biogenesis of such synthetic NBs demonstrates knowledge of the basic mechanisms involved. Application of this approach to the nucleolus, a paradigm of nuclear organization, has highlighted a key role for mitotic bookmarking in the cell cycle propagation of NBs.
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