期刊
CELL CYCLE
卷 13, 期 3, 页码 353-357出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.27769
关键词
colorectal cancer; cancer subtypes; consensus clustering; therapy resistance; MSI; CIMP; cetuximab; serrated pathway
类别
资金
- KWF Fellowship (Dutch Cancer Society)
- NHS
- Swiss National Science Foundation
Recently we published two independent studies describing novel gene expression-based classifications of colorectal cancer (CRC). Notably, each study stratified CRC into a different number of subtypes: one reported 3 subtypes, whereas the second highlighted 5. Given that each ascribed clinical significance, distinctive biology, and therapeutic prognosis to the different subtypes, we sought to reconcile this apparent incongruity in subtype stratification of CRC, and to interrelate the results. To do so, we each evaluated the other's data sets and analytical methods and discovered that the subtypes and their classifiers are, in fact, clearly related to each other; indeed, the 5 subtype outcomes can be coalesced into the same three. In addition to presenting this clarification, we briefly discuss how both classification methods can be viewed within the broader literature on CRC subtypes, and potentially applied.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据