相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr286, not Thr288
Anne L. Ashford et al.
BIOCHEMICAL JOURNAL (2014)
DYRK1A: A Potential Drug Target for Multiple Down Syndrome Neuropathologies
Walter Becker et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2014)
Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells
Nobuhiro Kurabayashi et al.
GENES & DEVELOPMENT (2013)
Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders
Takeshi Kawauchi et al.
GENES TO CELLS (2013)
Dosage of Dyrk1a Shifts Cells within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter the Cell Cycle
Jia-Yun Chen et al.
MOLECULAR CELL (2013)
Phenotypic Characterization of Retinoic Acid Differentiated SH-SY5Y Cells by Transcriptional Profiling
Joanna A. Korecka et al.
PLOS ONE (2013)
NGF Upregulates the Plasminogen Activation Inhibitor-1 in Neurons via the Calcineurin/NFAT Pathway and the Down Syndrome-Related Proteins DYRK1A and RCAN1 Attenuate This Effect
Georgios C. Stefos et al.
PLOS ONE (2013)
The DREAM complex: master coordinator of cell cycle-dependent gene expression
Subhashini Sadasivam et al.
NATURE REVIEWS CANCER (2013)
Co-ordination of cell cycle and differentiation in the developing nervous system
Christopher Hindley et al.
BIOCHEMICAL JOURNAL (2012)
Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control
Walter Becker
CELL CYCLE (2012)
p27KiP1 Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration
Juliette D. Godin et al.
DEVELOPMENTAL CELL (2012)
The DYRK1A gene is a cause of syndromic intellectual disability with severe microcephaly and epilepsy
Jean-Benoit Courcet et al.
JOURNAL OF MEDICAL GENETICS (2012)
Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B
Tania Tahtouh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Down syndrome: the brain in trisomic mode
Mara Dierssen
NATURE REVIEWS NEUROSCIENCE (2012)
Trisomy 21 and early brain development
Tarik F. Haydar et al.
TRENDS IN NEUROSCIENCES (2012)
DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation
Yoshihiko Miyata et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling
Barbara Haemmerle et al.
DEVELOPMENT (2011)
MNB/DYRK1A as a multiple regulator of neuronal development
Francisco J. Tejedor et al.
FEBS JOURNAL (2011)
DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
Larisa Litovchick et al.
GENES & DEVELOPMENT (2011)
Homeodomain-interacting Protein Kinase-2 Stabilizes p27kip1 by Its Phosphorylation at Serine 10 and Contributes to Cell Motility
Giovanna Maria Pierantoni et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
Xiumei Guo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells
Joongkyu Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells
Odessa Yabut et al.
JOURNAL OF NEUROSCIENCE (2010)
Phosphorylation of p27Kip1 at Thr187 by Cyclin-dependent Kinase 5 Modulates Neural Stem Cell Differentiation
Ya-Li Zheng et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
Cell cycle control of mammalian neural stem cells: putting a speed limit on G1
Paolo Salomoni et al.
TRENDS IN CELL BIOLOGY (2010)
Cdk4/CyclinD1 Overexpression in Neural Stem Cells Shortens G1, Delays Neurogenesis, and Promotes the Generation and Expansion of Basal Progenitors
Christian Lange et al.
CELL STEM CELL (2009)
Function and regulation of Dyrk1A: towards understanding Down syndrome
Joongkyu Park et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon
Andrea Tedeschi et al.
EMBO REPORTS (2009)
Deletion of the p107/p130-binding domain of Mip130/LIN-9 bypasses the requirement for CDK4 activity for the dissociation of Mip130/LIN-9 from p107/p130-E2F4 complex
Raudel Sandoval et al.
EXPERIMENTAL CELL RESEARCH (2009)
Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation
Nora Goeckler et al.
FEBS JOURNAL (2009)
Mirk Regulates the Exit of Colon Cancer Cells from Quiescence
Kideok Jin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Alternative Functions of Core Cell Cycle Regulators in Neuronal Migration, Neuronal Maturation, and Synaptic Plasticity
Christopher L. Frank et al.
NEURON (2009)
Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly
Rikke S. Moller et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma
Jan J. Molenaar et al.
CANCER RESEARCH (2008)
A drug-inducible system for direct reprogramming of human somatic cells to pluripotency
Dirk Hockemeyer et al.
CELL STEM CELL (2008)
Post-translational regulation of the tumor suppressor p27(KIP1)
J. Vervoorts et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Transferring genes into cultured mammalian embryos by electroporation
Masanori Takahashi et al.
DEVELOPMENT GROWTH & DIFFERENTIATION (2008)
The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development
Barbara Hammerle et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2008)
DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine
Anne Seifert et al.
FEBS JOURNAL (2008)
Retinoic acid downregulates Rae1 leading to APCCdh1 activation and neuroblastoma SH-SY5Y differentiation
J. Cuende et al.
ONCOGENE (2008)
Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome
Wieslaw K. Dowjat et al.
NEUROSCIENCE LETTERS (2007)
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-αB crystallin complex
Douglas I. Lin et al.
MOLECULAR CELL (2006)
Coupling cell cycle exit, neuronal differentiation and migration in cortical neurogenesis
Laurent Nguyen et al.
CELL CYCLE (2006)
DYRKIA BAC transgenic mice show altered synaptic plasticity with learning and memory defects
Kyoung-Jin Ahn et al.
NEUROBIOLOGY OF DISEASE (2006)
p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex
Laurent Nguyen et al.
GENES & DEVELOPMENT (2006)
Retinoic acid induces P27Kip1 nuclear accumulation by modulating its phosphorylation
A Borriello et al.
CANCER RESEARCH (2006)
Culturing hippocampal neurons
Stefanie Kaech et al.
NATURE PROTOCOLS (2006)
Cdk5 phosphorylates and stabilizes p27(kip1) contributing to actin organization and cortical neuronal migration
T Kawauchi et al.
NATURE CELL BIOLOGY (2006)
DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1
PA Kelly et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Selective lengthening of the cell cycle in the neurogenic subpopulation of neural progenitor cells during mouse brain development
F Calegari et al.
JOURNAL OF NEUROSCIENCE (2005)
Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288
YL Zou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G0 by Mirk/dyrk1B kinase
XB Deng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Retinoic acid, a regeneration-inducing molecule
M Maden et al.
DEVELOPMENTAL DYNAMICS (2003)
Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice
V Fotaki et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization
N Fujita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression
M Boehm et al.
EMBO JOURNAL (2002)
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
TG Hofmann et al.
NATURE CELL BIOLOGY (2002)
Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A
S Himpel et al.
BIOCHEMICAL JOURNAL (2001)
Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome
X Altafaj et al.
HUMAN MOLECULAR GENETICS (2001)
Overexpression of p27Kip1 lengthens the G1 phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells
T Mitsuhashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation
JR Alt et al.
GENES & DEVELOPMENT (2000)
Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells
M Encinas et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Phosphorylation at serine 10, a major phosphorylation site of p27Kip1, increases its protein stability
N Ishida et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)