相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity
Nicholas M. Levinson et al.
NATURE CHEMICAL BIOLOGY (2014)
Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma
Mike R. Russell et al.
CANCER RESEARCH (2013)
Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override
Neil Beeharry et al.
CELL CYCLE (2013)
Combination Drug Scheduling Defines a Window of Opportunity for Chemopotentiation of Gemcitabine by an Orally Bioavailable, Selective ChK1 Inhibitor, GNE-900
Elizabeth Blackwood et al.
MOLECULAR CANCER THERAPEUTICS (2013)
Identification of Preferred Chemotherapeutics for Combining with a CHK1 Inhibitor
Yang Xiao et al.
MOLECULAR CANCER THERAPEUTICS (2013)
Pazopanib Enhances Paclitaxel-Induced Mitotic Catastrophe in Anaplastic Thyroid Cancer
Crescent R. Isham et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy
Remko Prevo et al.
CANCER BIOLOGY & THERAPY (2012)
Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition
Amy D. Guertin et al.
CANCER CELL INTERNATIONAL (2012)
SKI-606, an Src Inhibitor, Reduces Tumor Growth, Invasion, and Distant Metastasis in a Mouse Model of Thyroid Cancer
Won Gu Kim et al.
CLINICAL CANCER RESEARCH (2012)
Preclinical Development of the Novel Chk1 Inhibitor SCH900776 in Combination with DNA-Damaging Agents and Antimetabolites
Ryan Montano et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Homologous recombination and its regulation
Lumir Krejci et al.
NUCLEIC ACIDS RESEARCH (2012)
Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Nicholas M. Levinson et al.
PLOS ONE (2012)
Dose Dependent Effects on Cell Cycle Checkpoints and DNA Repair by Bendamustine
Neil Beeharry et al.
PLOS ONE (2012)
Forced Mitotic Entry of S-Phase Cells as a Therapeutic Strategy Induced by Inhibition of WEE1
Marieke Aarts et al.
CANCER DISCOVERY (2012)
The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses
Bipasha Mukherjee et al.
NEOPLASIA (2012)
A decade of tyrosine kinase inhibitor therapy: Historical and current perspectives on targeted therapy for GIST
Jean-Yves Blay
CANCER TREATMENT REVIEWS (2011)
The power of chemotherapeutic engineering Arresting cell cycle and suppressing senescence to protect from mitotic inhibitors
Mikhail V. Blagosklonny
CELL CYCLE (2011)
Renal collecting system growth and function depend upon embryonic γ1 laminin expression
Dong-Hua Yang et al.
DEVELOPMENT (2011)
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease
Raquel Dominguez-Kelly et al.
JOURNAL OF CELL BIOLOGY (2011)
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
Theonie Anastassiadis et al.
NATURE BIOTECHNOLOGY (2011)
Comprehensive analysis of kinase inhibitor selectivity
Mindy I. Davis et al.
NATURE BIOTECHNOLOGY (2011)
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
Luis I. Toledo et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
Kristina A. Cole et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
Cynthia X. Ma et al.
TRENDS IN MOLECULAR MEDICINE (2011)
Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis
Danzhi Huang et al.
BIOINFORMATICS (2010)
Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase
Samuel McNeely et al.
CELL CYCLE (2010)
A Bifunctional Regulatory Element in Human Somatic Wee1 Mediates Cyclin A/Cdk2 Binding and Crm1-Dependent Nuclear Export
Changqing Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells
Leslie A. Parsels et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1
Alessandra Blasina et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Mechanisms of mitotic cell death induced by chemotherapy-mediated G(2) checkpoint abrogation
Celia Vogel et al.
CANCER RESEARCH (2007)
Role of checkpoint kinase 1 in preventing premature mitosis in response to gemcitabine
MA Morgan et al.
CANCER RESEARCH (2005)
A small molecule-kinase interaction map for clinical kinase inhibitors
MA Fabian et al.
NATURE BIOTECHNOLOGY (2005)
Potentiation of cytotoxicity of topoisomerase I poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe
AN Tse et al.
CANCER RESEARCH (2004)
Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors
S Blencke et al.
CHEMISTRY & BIOLOGY (2004)
Development of polyphosphate parameters for use with the AMBER force field
KL Meagher et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2003)
A new science-business paradigm in anticancer drug development
MV Blagosklonny
TRENDS IN BIOTECHNOLOGY (2003)
Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis
DH Yang et al.
DEVELOPMENTAL BIOLOGY (2002)
Sequential activation and inactivation of G2 checkpoints for selective killing of p53-deficient cells by microtubule-active drugs
MV Blagosklonny
ONCOGENE (2002)
Increasing the precision of comparative models with YASARA NOVA - a self-parameterizing force field
E Krieger et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2002)
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
H Zhao et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
分享论文
