期刊
CELL CYCLE
卷 13, 期 10, 页码 1602-1606出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.28562
关键词
aneuploidy; Xenopus oocyte; meiosis; spindle assembly checkpoint; karyotyping
类别
资金
- Natural Science and Engineering Research Council of Canada
The spindle assembly checkpoint, SAC, is a surveillance mechanism to control the onset of anaphase during cell division. SAC prevents anaphase initiation until all chromosome pairs have achieved bipolar attachment and aligned at the metaphase plate of the spindle. In doing so, SAC is thought to be the key mechanism to prevent chromosome nondisjunction in mitosis and meiosis. We have recently demonstrated that Xenopus oocyte meiosis lacks SAC control. This prompted the question of whether Xenopus oocyte meiosis is particularly error-prone. In this study, we have karyotyped a total of 313 Xenopus eggs following in vitro oocyte maturation. We found no hyperploid egg, out of 204 metaphase II eggs with countable chromosome spreads. Therefore, chromosome nondisjunction is very rare during Xenopus oocyte meiosis I, despite the lack of SAC.
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