Spinosad resistance in the housefly, Musca domestica, is due to a recessive factor on autosome 1

Spinosad is a new and highly promising insecticide with efficacy against a wide range of insects, including houseflies. Selection of the field collected houseflies produced a highly spinosad resistant (>150-fold) strain of housefly following 10 generations of selection. Spinosad resistance was a recessive trait linked to autosome 1 which could not be overcome with the insecticide synergists piperonyl butoxide, S,S, S-tributylphosphorotrithioate nor diethyl maleate. Selection for resistance to spinosad did not result in cross-resistance to other insecticides. These results suggest spinosad resistance in the housefly is due to a unique resistance mechanism. (C) 2003 Elsevier Science (USA). All rights reserved.